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. 2022 Nov 24;29(12):1159–1169. doi: 10.1038/s41594-022-00857-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a-h) Sections of cryo-EM density of SNAPc subunits overlaid with their respective atomic models. Densities are shown as a grey mesh, and sticks are shown for the model as coloured in Fig. 3. i) cryo-EM density of the TFIIB subunit overlaid to the atomic within the SNAPc containing Pol II PIC bound to U1 promoter in OC state. j) cryo-EM density of a region of TFIIF subunit overlaid to the atomic model within the SNAPc containing Pol II PIC bound to U1 promoter in OC state. d) Local map of SNAPc containing Pol II PIC bound to U1 promoter in OC state is low pass filtered to 5 Å. The corresponding map is fitted with SNAPc subunits representing map to model fit, in particular the ‘wing-2’ region modelled using AlphaFold2¹.