Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 24;29(12):1159–1169. doi: 10.1038/s41594-022-00857-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a, Schematic 2D representation of the U1 and U5 promoter sequences highlighting the binding motifs of the initiation machinery as observed in the cryo-EM structure: PSE (SNAPc), TBP binding site (TBP) and TSS (Pol II). The transcription start site (TSS) is denoted as +1, and negative and positive numbers indicate upstream and downstream positions. b, Cartoon representation of the SNAPc-containing Pol II PIC, as viewed from the front and top. The color codes for Pol II and the GTFs are consistently used throughout.