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. 2022 Nov 24;29(12):1159–1169. doi: 10.1038/s41594-022-00857-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a) Representative cryo-EM micrograph (out of 4842 in total) of the SNAPc-containing Pol II PIC bound to U5 promoter cryo-EM data collection. Scale bar – 240 Å. b) Representative 2D class averages of initially sorted datasets after merging. As in the case of U1 promoter dataset, a clear signal for SNAPc is detected adjacent to a well-defined PIC. c) Complete processing scheme. The optimized strategy from U1 promoter bound SNAPc-PIC dataset was used to obtain high resolution maps of SNAPc-PIC bound to U5 promoter. Final maps are coloured using the subunit color code in Fig. 1. The local resolution map of global and locally refined maps indicate the resolution range of final maps (scale bar).