Extended Data Fig. 2. Cryo-EM structure determination of microtubule-associated filaments of LRRK2^RCKW[I2020T] in the absence of MLi-2.

Schematic of data processing pipeline used to obtain the reconstruction of microtubule-associated LRRK2^RCKW[I2020T] filaments in the absence of MLi-2 (see Methods for details). Local resolution maps, Fourier Shell Correlation, directional FSC plots, and the distribution of voxel resolutions are shown for all reconstructions discussed in the text.