. 2022 Oct 10;60(1):36–50. doi: 10.1007/s12035-022-03060-6

Table 3.

CSF biomarkers concentrations

Patients N = 150	RMS N = 107	PMS N = 18	ONIND N = 15	OIND N = 10	p value
APRIL	60.4 (130.2) 58.7 [36.7–85.3]	95.5 (37.7) 94.8 [63.7–125.6]	69.0 (30.9) 64.7 [40.9–88.5]	71.1 (31.7) 65.9 [48.9–101.6]	0.003
BAFF	133.4 (72.8) 120.8 [85.6–163.5]	175.6 (61.6) 164.4 [114.3–229.0]	169.6 (62.3) 159.4 [123.6–199.4]	184.1 (53.1) 166.5 [150.2–238.6]	0.013
Chitinase 3 like 1, ng/ml	312.8 (436.9) 152.4 [96–253]	270.6 (161.4) 213.2 [154.6–342.7]	94.5 (39.3) 83.3 [75.4–105.5]	168.8 (77.1) 138.2 [123.8–217.0]	< 0.001*
CCL2	282.0 (130.2) 266.9 [201.2–353.3]	388.5 (178.2) 379.3 [262.2–447.1]	369.3 (114.7) 346.5 [266.7–461.9]	314.0 (54.7) 339.6 [249.1–359.3]	0.004
CXCL8	38.9 (49.3) 30.8 [24.3–40.2]	41.1 (15.3) 39.2 [29.8–53.0]	28.0 (8.8) 25.3 [22.2–33.7]	27.8 (7.4) 26.5 [21.4–33.9]	0.676
CXCL10	78.3 (86.0) 58.1 [36.9–91.9]	92.0 (61.6) 74.2 [52.6–122.2]	44.8 (22.8) 37.3 [30.7–60.6]	61.1 (44.0) 51.4 [27.3–75.6]	0.305
CXCL12	621.9 (366.5) 585.0 [372.6–819.2]	801.1 (463.2) 852.4 [396.3–1176.8]	691.2 (438.8) 538.5 [429.4–789.4]	676.3 (361.6) 697.5 [386.7–963.3]	0.321
CXCL13	19.8 (28.5) 11.5 [8.6–19.9]	12.7 (5.8) 11.3 [9.6–15.0]	6.9 (3.1) 6.7 [4.9–9.0]	11.1 (6.6) 8.0 [6.3–17.0]	< 0.001*

Patients
N = 150

RMS
N = 107

PMS
N = 18

ONIND
N = 15

OIND
N = 10

p value

APRIL

60.4 (130.2)

58.7 [36.7–85.3]

95.5 (37.7)

94.8 [63.7–125.6]

69.0 (30.9)

64.7 [40.9–88.5]

71.1 (31.7)

65.9 [48.9–101.6]

0.003

BAFF

133.4 (72.8)

120.8 [85.6–163.5]

175.6 (61.6)

164.4 [114.3–229.0]

169.6 (62.3)

159.4 [123.6–199.4]

184.1 (53.1)

166.5 [150.2–238.6]

0.013

Chitinase 3 like 1, ng/ml

312.8 (436.9)

152.4 [96–253]

270.6 (161.4)

213.2 [154.6–342.7]

94.5 (39.3)

83.3 [75.4–105.5]

168.8 (77.1)

138.2 [123.8–217.0]

< 0.001*

CCL2

282.0 (130.2)

266.9 [201.2–353.3]

388.5 (178.2)

379.3 [262.2–447.1]

369.3 (114.7)

346.5 [266.7–461.9]

314.0 (54.7)

339.6 [249.1–359.3]

0.004

CXCL8

38.9 (49.3)

30.8 [24.3–40.2]

41.1 (15.3)

39.2 [29.8–53.0]

28.0 (8.8)

25.3 [22.2–33.7]

27.8 (7.4)

26.5 [21.4–33.9]

0.676

CXCL10

78.3 (86.0)

58.1 [36.9–91.9]

92.0 (61.6)

74.2 [52.6–122.2]

44.8 (22.8)

37.3 [30.7–60.6]

61.1 (44.0)

51.4 [27.3–75.6]

0.305

CXCL12

621.9 (366.5)

585.0 [372.6–819.2]

801.1 (463.2)

852.4 [396.3–1176.8]

691.2 (438.8)

538.5 [429.4–789.4]

676.3 (361.6)

697.5 [386.7–963.3]

0.321

CXCL13

19.8 (28.5)

11.5 [8.6–19.9]

12.7 (5.8)

11.3 [9.6–15.0]

6.9 (3.1)

6.7 [4.9–9.0]

11.1 (6.6)

8.0 [6.3–17.0]

< 0.001*

All values are reported as mean (standard deviation) in the first row and median [interquartile range] in the second row. In bold are reported significant differences at a two-sided α level < 0.05. A single asterisk (*) for non-parametric tests. CSF, cerebrospinal fluid.