Table 2.

DUBs in neurodegenerative diseases

Disease	DUB	Interactor/substrate	Functional implications of the DUB	Reference
PD	USP8	α-synuclein	Prevent lysosomal degradation of α-synuclein	[41]
PD	USP10	P62	Induce synaptic aggregates formation	[42]
PD	USP24	ULK1	Downregulate autophagic flux	[43]
PD	USP33	Parkin	Inhibit mitophagy	[44]
AD	OTUB1	Tau	Promote tau protein stability and aggregation	[45]
AD	USP46	AMPARs	Regulate synaptic receptor levels	[46]
HD	ATXN3	Beclin-1	Regulate autophagy	[47]
ALS	USP7	Nedd4L	Regulate SMAD-mediated protein quality control system	[48]

Only the direct interactors/substrates for E3s and DUBS are listed. For each disease, the list is sorted alphabetically by “DUB”