Table 3.

Potential inhibitors of DUBs involved in therapeutic implications in neurodegenerative diseases

Disease	Compounds	Target protein	Functional implication of the compound	References
PD	CMPD-39	USP30	Enhance peroxisome turnover and mitophagy	[173]
PD	FT3967385	USP30	Accelerate PINK1 generation of phospho-Ser65 ubiquitin	[174]
AD	IU1	USP14	Accelerate tau degradation	[175–177]
AD	LDN57444	UCHL1	Inhibit tau aggregation and affect APP processing	[178–180]
ALS	HBX41108	USP7	Inhibit the toxicity of the mutant SOD1 in neurons	[181]

For each disease, the list is sorted alphabetically by “Compounds”