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. 2022 Dec 16;8:172. doi: 10.1038/s41531-022-00439-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The graphs demonstrate the actual clinical values of each subtype overtime for vital signs (DIASTND standing diastolic blood pressure (BP), DIASUP supine diastolic BP, HRSTND standing heart rate, HRSUP supine heart rate, SYSSTND standing systolic BP, SYSSUP supine systolic BP, HTCM height in cm, TEMPC: temperature in C, WGTKG weight in kg), cerebrospinal fluid (abeta_42 β-amyloid 1–42, alpha_syn alpha-synuclein, p_tau181p phospho-tau181, total_tau total tau protein), and serum neurofilament light levels (serum_nfl). BL: Baseline. V04 visit number 4 after 12 months. V06: visit number 6 after 24 months. V08 visit number 8 after 36 months. V10 visit number 10 after 48 months. V12 visit number 12 after 60 months. In all panels, data is presented as mean ± s.e.m.