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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Hepatology. 2022 Jul 15;77(2):456–465. doi: 10.1002/hep.32609

Fig. 6. Schematic summary of the main findings.

Fig. 6.

Eosinophil-derived IL-4/IL-13, through inhibition of IFN-γ, protect against APAP-induced liver injury. Eosinophils produce IL-4/IL-13 in response to IL-33 stimulation. IL-33 activated p38MAPK, resulting in cyclooxygenase activity, which triggers NF-κB-mediated IL-4/IL-13 production.