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. 2022 Dec 17;87:104414. doi: 10.1016/j.ebiom.2022.104414

Fig. 6.

Fig. 6

Detection and neutralising auto-Abs against IFN-α2 and/or IFN-ω in FFP versus CCP.(A) Gyros (high-throughput automated ELISA) results for auto-Abs against IFN-α2 and IFN-ω in the FFP (n = 166) considered as the reference versus CCP (n = 766). (B) Results for the neutralisation of 100 pg/mL IFN-α2 or IFN-ω in the presence of 10% plasma in the FFP (n = 166) versus CCP (n = 766). Relative luciferase activity is shown (ISRE dual luciferase activity, with normalisation against Renilla luciferase activity) after stimulation with 100 pg/mL IFN-α2 or IFN-ω in the presence of 10% plasma. RLU: relative luciferase units. ISRE: interferon-sensitive response elements. Dotted lines indicate neutralising levels, defined as induction levels below 15% of the median value for controls tested on the same day.