Fig. 4.
Elevated salience network connectivity in Aβ+ participants. A) Relative to Aβ- participants, Aβ+ participants had greater mean overall connectivity across all 74 ipsilateral and contralateral salience network node-pairs. B) Aβ+ participants had higher connectivity than Aβ- participants (pBONFERRONI < 0.05) in two specific salience network node-pairs: (1) left amygdala (ROI 8) – PAG (ROI 21) and (2) left anterior midcingulate cortex (ROI 4) – right subgenual ACC (ROI 17). These analyses controlled for fixed effects of age, sex, the interval in days between participants’ tf-fMRI and PET scans (tf-fMRI – PET), and APOE*E4 status as well as random intercepts for each participant. At the time of the neuroimaging assessment, one Aβ+ participant (and two Aβ- participants) had converted to MCI. ACC, anterior cingulate cortex; aMCC, anterior midcingulate cortex; Amy, amygdala; and PAG, periaqueductal gray.