Table 3.

Univariable and multivariable predictors of death or retransplantation.

	HR (95% CI)	p-value	HR (95% CI)	p-value
MBFR≤2	7.05 (3.2–15.5)	<0.0001	4.04 (1.72–9.46)	0.001
Donor Age	0.99 (0.97–1.03)	0.82
Age	1.008 (0.99–1.03)	0.50
Non-white	0.93 (0.47–1.81)	0.83
Time Since Transplant	1.04 (0.99–1.10)	0.15
Female	0.30 (0.11–0.86)	0.02
Rest EF	0.95 (0.92–0.98)	0.004	0.95 (0.92–1.00)	0.04
ISHLT CAV 2 or 3	4.56 (1.99–10.46)	0.0003	2.68 (1.07–8.46)	0.04
PET Assessed Ischemia (SDS>2)	6.14 (2.80–13.16)	<0.0001	3.70 (1.62–8.46)	0.002
Ischemic Cardiomyopathy	1.49 (0.73–3.04)	0.27
PSI	0.47 (0.18–1.21)	0.12
Statin	0.52 (0.23–1.14)	0.10	0.34 (0.14–0.80)	0.01
Aspirin	1.15 (0.35–3.77)	0.81
Pre-Transplant Cigarette Use	1.25 (0.63–2.49)	0.42
Diabetes Mellitus	3.51 (1.77–6.97)	0.0003	3.67 (1.71–7.88)	0.001
Prior Stroke	2.41 (0.74–7.88)	0.15
BMI	0.99 (0.93–1.04)	0.59
Stage 3+ CKD (GFR<60 ml/min/1.73 m2)	0.66 (0.73–3.81)	0.23
DSA	1.77 (0.91–3.47)	0.09
Prior ACR	1.55 (0.78–3.08)	0.21
Prior AMR	2.66 (1.10–6.41)	0.03

ACR=Acute cellular rejection, AMR=Antibody mediated rejection, BMI=Body mass index, CAV=Cardiac allograft vasculopathy, CKD=Chronic kidney disease, DSA=Donor specific antibodies, EF=Ejection fraction, MBFR=Myocardial blood flow reserve, PSI=Proliferation signal inhibitor, SDS=Summed difference score