Table 3.
Changes in levels and trends of availability, utilization, and cost for the intervention group and control group
| Category | Level and trend |
Trend estimation after NDPN policy intervention | |||
|---|---|---|---|---|---|
|
|
Baseline level
|
Baseline trend
|
Level change immediately after NDPN Policy intervention
|
Trend change after NDPN policy intervention
|
|
|
Availability (%)
| |||||
| Intervention group |
2.26 (95% CI = 1.92, 2.61, P < 0.001) |
0.22 (95% CI = 0.18, 0.26, P < 0.001) |
7.88 (95% CI = 4.31, 11.45, P < 0.001) |
1.23 (95% CI = 0.81, 1.64, P < 0.001) |
1.45 (95% CI = 1.03, 1.86, P < 0.001) |
| Comparison group |
10.14 (95% CI = 8.81, 11.48, P < 0.001) |
0.56 (95% CI = 0.41, 0.71, P < 0.001) |
-0.98 (95% CI = -1.84, -0.13, P = 0.026) |
-0.31 (95% CI = -0.46, -0.16, P < 0.001) |
0.25 (95% CI = 0.24, 0.27, P < 0.001) |
| Differences between the intervention and control group |
-7.88 (95% CI = -9.22, -6.54, P < 0.001) |
-0.34 (95% CI = -0.49, -0.19, P < 0.001) |
8.86 (95% CI = 5.29, 12.44, P < 0.001) |
1.53 (95% CI = 1.10, 1.96, P < 0.001) |
1.19(95% CI = 0.79, 1.59, P < 0.001) |
|
Utilization (DDDs)
| |||||
| Intervention group |
3.48 (95% CI = 3.01, 3.96, P < 0.001) |
0.07 (95% CI = 0.01, 0.12, P = 0.018) |
12.66 (95% CI = 5.83, 19.48, P = 0.001) |
3.10 (95% CI = 2.21, 3.99, P < 0.001) |
3.17 (95% CI = 2.28, 4.05, P < 0.001) |
| Comparison group |
11.83 (95% CI = 9.70, 13.96, P < 0.001) |
0.60 (95% CI = 0.21, 0.99, P = 0.004) |
1.22 (95% CI = -5.05, 7.49, P = 0.691) |
-0.44 (95% CI = -1.08, 0.20, P = 0.172) |
0.17 (95% CI = -0.35, 0.68, P = 0.508) |
| Differences between the intervention and control group |
-8.35 (95% CI = -10.47, -6.22, P < 0.001) |
-0.54 (95% CI = -0.92, -0.16, P = 0.007) |
11.44 (95% CI = 2.42, 20.46, P = 0.014) |
3.54(95% CI = 2.47, 4.60, P < 0.001) |
3.00 (95% CI = 2.01, 3.99, P < 0.001) |
|
Cost (DDDc in US$)
| |||||
| Intervention group |
251.84 (95% CI = 235.02, 268.67, P < 0.001) |
-2.74 (95% CI = -6.12. 0.64, P = 0.107) |
-124.50 (95% CI = -155.87, -93.13, P < 0.001) |
2.80 (95% CI = -0.58, 6.18, P = 0.100) |
0.06 (95% CI = -0.06, 0.18, P = 0.282) |
| Comparison group |
1308.80 (95% CI = 1301.46, 1316.14, P < 0.001) |
-0.24 (95% CI = -1.82. 1.33, P = 0.752) |
-15.41 (95% CI = -43.47, 12.66, P = 0.268) |
0.33 (95% CI = -3.67, 4.33, P = 0.866) |
0.09 (95% CI = -3.59, 3.76, P = 0.961) |
| Differences between the intervention and control group | -1056.96 (95% CI = -1074.82, -1039.10, P < 0.001) | -2.49 (95% CI = -6.12. 1.13, P = 0.173) | -109.09 (95% CI = -150.05, -68.14, P < 0.001) | 2.47 (-2.63, 7.56, P = 0.334) | -0.03 (95% CI = -3.60, 3.55, P = 0.989) |
NDPN – national drug price negotiation, DDDs – defined daily doses; DDDc – defined daily dose cost, CI – confidence interval