Fig. 1.

Multimodal analysis of children and adults with mild COVID-19.

(A) Study overview.

(B) Patient demographic and clinical severity score. For A13 the second blood sample was collected on day 8 during the acute phase.

(C) Serum anti-S protein antibodies.

(D) CD38⁺HLA-DR⁺ activated CD4⁺ (left) and CD8⁺ (right) T cells in children, non-ICU, and ICU adults during Acute and Convalescent phases.

(E) Serum TNF, IL-6, IL-10, and interferon-α levels.

(F) UMAP showing 433,301 single cells from children, non-ICU, and ICU adults during Acute and Convalescent phases.

(G) Stacked barplot showing cellular composition of PBMCs in children, non-ICU, and ICU adults during Acute (top) and Convalescent (bottom) phases from the single cell RNA sequencing.