Table 2.
Ovarian stimulation characteristics of two treatment protocols
| Original cohort | P | PSM cohort | P | |||
|---|---|---|---|---|---|---|
| Group A (n = 168) | Group B (n = 114) | Group A (n = 71) | Group B (n = 71) | |||
| Gonadotropin dosage (IU) | 2639.36 ± 741.08 | 2697.37 ± 968.87 | 0.570 | 2406.69 ± 564.97 | 2930.28 ± 1040.40 | 0.001 |
| Duration of stimulation (days) | 9.77 ± 1.63 | 11.84 ± 2.98 | < 0.001 | 9.49 ± 1.29 | 11.93 ± 3.05 | < 0.001 |
| Number of oocytes retrieved (n) | 7.00 (4.00–10.00) | 10.00 (7.00–12.75) | < 0.001 | 8.00 (6.00–12.50) | 9.00 (6.00–12.00) | 0.978 |
| Fertilization type (n, %) | 0.162 | 0.431 | ||||
| IVF | 144 (85.71%) | 88 (77.19%) | 62 (87.32%) | 57 (80.28%) | ||
| ICSI | 19 (11.31%) | 22 (19.30%) | 8 (11.27%) | 11 (15.49%) | ||
| IVF + ICSI | 5 (2.98%) | 4 (3.51%) | 1 (1.41%) | 3 (4.23%) | ||
| Number of fertilization (n) | 6.00 (4.00–8.00) | 8.00 (5.00–10.00) | 0.001 | 7.00 (5.00–10.50) | 7.00 (5.00–10.00) | 0.606 |
| 2PN(n) | 4.00 (3.00–7.00) | 6.00 (4.00–8.00) | 0.002 | 6.00 (4.00–7.50) | 5.00 (4.00–8.00) | 0.766 |
| Number of available embryos (n) | 4.00 (3.00–6.00) | 5.00 (3.00–7.00) | 0.011 | 5.00 (3.00–700) | 5.00 (2.50–700) | 0.818 |
| Number of high-quality embryos (n) | 2.00 (1.00–4.00) | 3.00 (2.00–5.00) | 0.080 | 3.00 (2.00–5.00) | 3.00 (2.00–5.00) | 0.461 |
| Number of transferred embryos (n, %) | 0.420 | 0.263 | ||||
| 1 | 96 (57.14%) | 68 (59.65%) | 49 (69.01%) | 41 (57.75%) | ||
| 2 | 72 (42.86%) | 45 (39.47%) | 22 (30.99%) | 29 (40.85%) | ||
| 3 | 0 (0.00%) | 1 (0.88%) | 0 (0.00%) | 1 (1.41%) | ||
| Number of transferred high-quality embryos (n, %) | 0.007 | 0.009 | ||||
| 0 | 69(41.07%) | 39(34.21%) | 30(42.25%) | 24(33.80%) | ||
| 1 | 91(54.17%) | 57(50.00%) | 40(56.34%) | 33(46.68%) | ||
| 2 | 8(4.76%) | 18(15.79%) | 1(1.41%) | 14(19.72%) | ||
| Embryo stage (n, %) | 0.002 | >0.99 | ||||
| Cleavage stage | 99 (58.93%) | 46 (40.35%) | 32 (45.07%) | 33 (46.48%) | ||
| Blastocyst stage | 69 (41.07%) | 68 (59.65%) | 39 (54.93%) | 38 (53.52%) | ||
Note: Group A = GnRH antagonist protocol and freeze-all strategy; Group B = long-acting GnRH agonist protocol; PSM = propensity-score matching; IVF = in vitro fertilization; ICSI = intracytoplasmic sperm injection; 2PN = two pronuclear