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Illustration of common designs of BBB targeting antibody or protein designs. The illustration was based on individual references listed in the articles. (1) TfRMAb-IDUA [134], (2) ETV:IDS [123,124], (3) cTfRMAb-ScFv [130], (4) anti-TfR/BACE1 [121], (5) ATV:BACE1 [122], (6) PTV:PGRN [125], (7) Ab18 TVD-Ig/αTfR [137].
