Table 3.
Reference intervals ([2.5th-97.5th percentile] of entire baseline cohort) of thrombin generation parameters and out of ranges results after 6 cycles of treatment
| ETP (nM.min) | Peak height (nM) | Lag time (min) | Time to peak (min) | mVRI (nM/min) | |
|---|---|---|---|---|---|
| Reference ranges | 906-1562 | 119.6 −282.0 | 2.09-3.80 | 5.00-8.64 | 24.8-111.0 |
| EE/LNG (N = 25) | 10(42%) | 14 (58%) | 0 (0%) | 6 (25%) | 10 (42%) |
| EE/DRSP (N = 28) | 18 (64%) | 22 (79%) | 2 (7%) | 12 (43%) | 19 (68%) |
| E4/DRSP (N = 34) | 11 (32%) | 9 (26%) | 0 (0%) | 5 (15%) | 9 (26%) |
Abbreviations: DRSP, drospirenone; E4, estetrol; EE, ethinylestradiol; ETP, endogenous thrombin potential; LNG, levonorgestrel; mVRI, mean velocity rate index.