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Untargeted metabolomic profile of participants serum. A, Scheme of design: 40 healthy control (Con), 41 patients diagnosed as subclinical hypothyroidism (SCH), and 45 patients with clinical hypothyroidism were included. B, Principal component analysis (PCA) based on all features, top 2 PCs explaining the largest variation were shown. C, Heatmap of metabolites with false discovery rate (FDR) <0.05 in ANOVA.
