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. 2022 Jan 2;155:111724. doi: 10.1016/j.chaos.2021.111724

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Fig 1 — Modeling the crosstalk between pyroptosis and secondary pyroptosis network. (A) The simplified regulatory network of pyroptosis and secondary pyroptosis signaling. (B) Comparison between experimental data (dots) and simulation results (lines) of the constituent time-course responses. The results of three different single constituent knockout conditions are colored by black (wild-type, WT), red (GSDMD knockout, GSDMD-KO) and blue (caspase-1 knockout, Casp1-KO). (C) Comparison between experimental data (dots) and simulation results (lines) in GSDME KO, GSDMD/BID DKO, GSDMD/Casp1 DKO, GSDMD/Casp8 DKO, GSDMD/Casp9 DKO, and GSDMD/Casp8/Casp9 TKO BMDMs. (D) Scatter diagram of experimental data versus simulation results. There are 27 comparison results for wild-type (WT), 78 comparison results for single knockout (KO), 30 comparison results for double knockout (DKO) and 3 comparison results for triple knockout (TKO) with a total of 138 comparison results. R² reflects the correlation strength between simulation results and experimental data.