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Sensitivity analysis of constituent levels and reaction parameters. (A-B) The response curves and two-dimensional heat maps of GSDMD (A) and GSDME (B) to the level change from 0.001 nM to 1000 nM for the seven constituents. (C) The two-dimensional heat maps of GSDMD (upper panel) and GSDME (down panel) with the value change from 10−7 to 10−2 for the reaction rates. (D) The two-dimensional heat maps of GSDMD and GSDME with the value change from 0.001 to 1000 for the Michaelis constants.
