Fig. 4.

Roles of reaction parameters in death modes switching. (A) Bifurcation diagrams of GSDMD and GSDME as function of the activation rate of caspase-1induced by stimuli (k_{S_C1}). Stable and unstable steady states are indicated by solid and dashed lines, respectively. (B) The contribution proportions of pyroptosis and secondary pyroptosis to cell death for points a-c in Fig. 4A, respectively. (C) Bifurcation diagrams of GSDMD and GSDME as function of the activation rate of GSDMD induced by caspase-1(k_{C1_GD}). (D) The contribution proportions of pyroptosis and secondary pyroptosis to cell death for points A-D in Fig. 4C, respectively. (E) Bifurcation diagrams of GSDMD and GSDME as function of the activation rate of caspase-3 induced by caspase-1 (k_{C1_C3}). (F) The contribution proportions of pyroptosis and secondary pyroptosis to cell death for points 1–3 in Fig. 4E, respectively.