Fig. 7.

Diverse states transition meditated by caspase-1 level and k_{C1_GD}. (A) Bifurcation diagrams of GSDMD and GSDME as function of caspase-1 level (C1tot) when k_{C1_GD}=3 × 10⁻⁵ s⁻¹. As C1tot increases, the system presents monostability (region I), bistability (region II), monostability (region III), and bistability (region IV) in turn. (B–E) Landscapes at different expression levels of caspse-1 (C1tot) when k_{C1_GD}=3 × 10⁻⁵ s⁻¹. (F) The occurrence probabilities of pyroptosis and secondary pyroptosis change as C1tot changes. (G) Phase diagram of the system stability on k_{C1_GD} with respect to C1tot. The blue area represents the monostable region (M) and pink area represents the bistable region (B).