Fig. 8.

Phase diagram of the system stability on the vital constituent levels and reactions. (A–C) Phase diagrams of the system stability on one of the three constituents level (C1tot, C3tot, and GDtot) with respect to another constituent. (D–F) Phase diagrams of the system stability on k_{C1_GD} (activation rate of GSDMD induced by caspase-1) with respect to the level of the three constituents, C1tot (D), C3tot (E) and GDtot (F). (G-H) Phase diagrams of the system stability on k_{C1_GD} (activation rate of GSDMD induced by caspase-1) with respect to the 2 key parameters, k_{S_C1} (activation rate of caspase-1 induced by stimuli) (G) and d_C1 (inactivation/degradation rate of caspase-1) (H). (I) Phase diagram of the system stability on d_GD (inactivation/degradation rate of GSDMD) with respect to d_C3 (inactivation/degradation rate of caspase-3).