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. 2022 Jul 28;31(24):4207–4216. doi: 10.1093/hmg/ddac172

Figure 7.

Figure 7

A convergent signaling pathway underlying the KS-linked genes. (A) Expression profiles of the chromatin regulator Chd7 upon the two knockdown experiments. **P-value < 0.01; one-tailed t-test. (B) Heatmap of Chd7 ChIP-seq profiles at the promoter regions of the 1052 overlapping DEGs. (C) Chd7 ChIP-seq profiles at the promoter regions of the 1052 overlapping DEGs and the 1000 control genes (Ctrl). (D) Proposed model of the convergent pathway underlying the KS-linked genes Hs6st1, Fgf, Fgfr1, Sox10 and Chd7. HS, heparan sulfate. HSPG, heparan sulfate proteoglycan.