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Operating principle of the SERS-based LFA sensing platform. LFA strips for Y. pestis, F. tularensis, and B. anthracis were dipped into wells of a 96-well ELISA plate containing mixtures of SERS nanotags and different concentrations of bacteria in the buffer solution. The formed immunocomplexes migrated through the capillary action toward to the test line, where their Raman signals were measured and analyzed. Reprinted with permission from Ref. [113]. Copyright 2018 Elsevier Science.
