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. 2022 Dec 17;12:21820. doi: 10.1038/s41598-022-24276-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Receiver operating characteristic (ROC) curves using only T1 (blue), only T2 (red), the Euclidian norm of T1 and T2 –normT1T2- (yellow) and the Euclidian norm of the logarithm of T1 and T2 –normlog- (purple). (a) ROC curves between the abnormal tissue (ABN) and normal white matter (nWM), (b) ROC curves between the T1w-enhanced region (T1e) and the rest of the voxels (T2 hyperintensity region -T2h − + perilesional area -PER − + nWM), and (c) ROC curves between T1e and T2h. The point with the highest Youden’s index is marked with a black circle.