Table 2.
Cox proportional hazards model univariable and multivariable analysis of ICU mortality-associated factors in patients with definite intestinal necrosis
| Characteristics of necrosis population | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| CSH | 95% CI | P value | CSH | 95% CI | P value | |
| Age (+ 10 years) | 1.32 | 0.92–1.90 | 0.13 | 1.67 | 1.01–2.80 | 0.04 |
| Males | 1.44 | 0.61–3.39 | 0.41 | – | – | – |
| Body mass index (kg/m2) | 0.99 | 0.92–1.06 | 0.74 | – | – | – |
| Diabetes | 0.86 | 0.20–3.71 | 0.85 | – | – | – |
| Hypertension | 0.55 | 0.23–1.31 | 0.18 | – | – | – |
| Smoking | 1.19 | 0.51–2.77 | 0.68 | – | – | – |
| Coronary disease | 0.69 | 0.27–1.79 | 0.45 | – | – | – |
| Peripheral arterial disease | 0.66 | 0.15–2.83 | 0.57 | – | – | – |
| End stage renal disease | 2.06 | 0.27–16.2 | 0.49 | – | – | – |
| Atrial fibrillation | 0.77 | 0.26–2.28 | 0.63 | – | – | – |
| Abdominal distension | 2.47 | 1.05–5.86 | 0.04 | 4.99 | 1.62–15.3 | 0.005 |
| SOFA at day of suspicion | 0.99 | 0.87–1.13 | 0.93 | – | – | – |
| Biological parameters | ||||||
| Lactate (mmol/L) | 1.10 | 1.02–1.19 | 0.03 | 1.17 | 1.05–1.30 | 0.005 |
| pH (+ 0.1 unit) | 0.69 | 0.50–0.94 | 0.02 | – | – | – |
| Bicarbonates | 0.97 | 0.89–1.06 | 0.52 | – | – | – |
| LDH (+ 300 units) | 1.02 | 0.99–1.06 | 0.21 | – | – | – |
| CPK (+ 1.000 units) | 1.001 | 0.98–1.02 | 1 | – | – | – |
| Aspartate transaminase (+ 100 units) | 1.001 | 0.98–1.02 | 0.94 | – | – | – |
| Procalcitonin (µg/L) | 0.97 | 0.89–1.06 | 0.52 | – | – | – |
| Positive blood cultures | 0.93 | 0.36–2.37 | 0.87 | – | – | – |
| Candidemia | 1.50 | 0.43–5.22 | 0.52 | – | – | – |
| Specific biomarkers | ||||||
| Plasma I-FABP (+ 1.000 units) | 1.02 | 1.01–1.03 | 0.02 | 1.00 | 0.99–1.02 | 0.67 |
| Citrulline (µmol/mL) | 1.02 | 0.98–1.05 | 0.32 | – | – | – |
| Arginine (µmol/mL) | 1.01 | 0.99–1.02 | 0.09 | – | – | – |
| Plasma citrulline/arginine ratio | 1.06 | 0.54–2.08 | 0.87 | – | – | – |
| CT findings | ||||||
| Abnormal wall enhancement | 0.93 | 0.34–2.48 | 0.87 | – | – | – |
| Pneumatosis intestinalis | 1.54 | 0.43–5.48 | 0.50 | – | – | – |
| Bowel dilation | 0.76 | 0.28–2.05 | 0.59 | – | – | – |
| Portal venous gas | 0.30 | 0.04–2.32 | 0.25 | – | – | – |
| Atherosclerosis of mesenteric arteries | 0.89 | 0.29–2.79 | 0.85 | – | – | – |
| Organ supports at inclusion | ||||||
| Norepinephrine (μg/kg/mn) | 1.20 | 1.03–1.41 | 0.01 | – | – | – |
| Mechanical ventilation | 3.07 | 0.41–23.0 | 0.27 | – | – | – |
| Renal replacement therapy | 1.10 | 0.32–3.74 | 0.88 | – | – | – |
| Surgical treatment | ||||||
| Resection | 0.31 | 0.12–0.75 | 0.01 | 0.49 | 0.18–1.33 | 0.16 |
CSH cause-specific hazard ratio, SOFA Sequential Organ-Failure Assessment