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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: J Orthop Res. 2022 Jun 25;41(3):663–673. doi: 10.1002/jor.25401

FIGURE 3.

FIGURE 3

OCM lesion at the distal humerus of a 12-week-old pig. (A) A hyperintense region within the cartilage in the 3D DESS image (white arrows) that corresponds to (B) an area with increased T2 values (yellow to green) within the articular epiphyseal cartilage complex (black arrows) in the T2 map with (C) corresponding histological section showing associated region of thickened articular–epiphyseal cartilage complex with delay of endochondral ossification and locally extensive subjacent chondroid matrix necrosis (outlined in black), consistent with OCM in the distal humerus of a 12-week-old pig. H&E, 0.5× magnification. (D) Corresponding T1ρ map with increased T1ρ values (orange and yellow) in the OCM lesion (black arrows). (E) High magnification image oriented with the articular surface towrads the top of the panel (not pictured) showing clefting between the thickened articular–epiphyseal cartilage complex and the subjacent area of necrosis, with fibrosis extending into the subchondral bone (bright pink). H&E, 10× magnification; scale bar = 100 μm. (F) High magnification image (40×) of the area within the box in (E) demonstrating necrotic chondrocytes (black arrowheads), overlying a cleft (*) and accumulation of eosinophilic necrotic debris. H&E, 40× magnification; scale bar = 50 μm. H&E, hematoxylin & eosin; OCM, osteochondrosis manifesta.