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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: J Orthop Res. 2022 Jun 25;41(3):663–673. doi: 10.1002/jor.25401

FIGURE 4.

FIGURE 4

OCM lesion at the distal femur of a 12-week-old pig. (A) A hyperintense region (white arrow) within the cartilage in the 3D DESS image (white to pale gray) that corresponds to (B) an area with increased T2 values (orange to yellow) in a wedge shape within the articular epiphyseal cartilage complex (black arrow) in the T2 map with (C) corresponding histological section showing a region of focal delay of endochondral ossification and chondrocyte necrosis with matrix pallor (black circle), consistent with OCM in the distal femur of a 12-week-old pig. H&E, 0.5× magnification; scale bar = 5 mm. (D) Corresponding T1ρ map with increased T1ρ values (orange to yellow) in the OCM lesion (black arrow). (E) High magnification image oriented with the articular surface towards the top of the panel (not pictured) showing focal delay of endochondral ossification (black arrows) and pale matrix and necrotic chondrocytes. H&E, 4× magnification; scale bar = 500 μm. (F) High magnification image of the area indicated by the box in (E) demonstrating necrotic chondrocytes (black arrowheads) with diffuse eosinophilia and pallor of the associated matrix surrounding a necrotic vascular profile (*). H&E, 20× magnification; scale bar = 50 μm. H&E, hematoxylin & eosin; OCM, osteochondrosis manifesta.