Table 2.
Differential vulnerability of major WM structures to CMB-related cognitive change.
| structure | N | cognitive ability | measure | r | t | q |
|---|---|---|---|---|---|---|
| corpus callosum | 25 | attention | FA | 0.52 | 2.92 | 0.01 |
| MD | 0.44 | 2.35 | 0.02 | |||
| RD | 0.45 | 2.42 | 0.01 | |||
| executive functions | FA | 0.39 | 2.03 | 0.03 | ||
| MD | 0.37 | 1.91 | 0.03 | |||
| RD | 0.61 | 3.69 | 0.01 | |||
| memory | FA | 0.52 | 2.92 | 0.01 | ||
| MD | 0.50 | 2.77 | 0.01 | |||
| language | FA | 0.42 | 2.22 | 0.02 | ||
| RD | 0.35 | 1.79 | 0.01 | |||
| visuo-constructional | FA | 0.41 | 2.22 | 0.01 | ||
| MD | 0.39 | 2.03 | 0.01 | |||
| cingulum bundle | 31 | attention | FA | 0.49 | 3.03 | 0.01 |
| RD | 0.39 | 2.28 | 0.02 | |||
| executive functions | FA | 0.42 | 2.49 | 0.01 | ||
| MD | 0.48 | 2.95 | 0.01 | |||
| memory | FA | 0.39 | 2.28 | 0.02 | ||
| visuo-constructional | FA | 0.40 | 2.35 | 0.01 | ||
| inferior longitudinal fasciculus | 20 | executive functions | FA | 0.45 | 2.35 | 0.02 |
| MD | 0.42 | 2.14 | 0.03 | |||
| memory | FA | 0.41 | 2.13 | 0.04 | ||
| language | FA | 0.37 | 1.96 | 0.05 | ||
| visuo-constructional | FA | 0.40 | 1.91 | 0.04 | ||
| inferior occipito-frontal fasciculus | 39 | attention | FA | 0.39 | 2.58 | 0.01 |
| MD | 0.35 | 2.27 | 0.02 | |||
| RD | 0.38 | 2.50 | 0.01 | |||
| language | FA | 0.37 | 2.42 | 0.01 | ||
| visuo-constructional | FA | 0.51 | 3.61 | 0.03 | ||
| middle longitudinal fasciculus | 27 | attention | FA | 0.36 | 1.93 | 0.03 |
| RD | 0.38 | 2.05 | 0.03 | |||
| MD | 0.44 | 2.45 | 0.01 | |||
| language | FA | 0.41 | 2.25 | 0.02 | ||
| corona radiata | 36 | executive functions | MD | 0.46 | 3.02 | 0.01 |
| FA | 0.30 | 1.84 | 0.04 | |||
| orientation | MD | 0.33 | 2.04 | 0.03 | ||
| FA | 0.42 | 2.70 | 0.01 |
Listed are the results of testing the null hypothesis of no significant correlation r between (A) changes in MoCA sub-scores for individual cognitive abilities (second column) and (B) changes in diffusion properties near CMBs located within WM structures (first column). The null hypothesis was tested across all mTBI participants with CMBs at α = 0.05 with multiple comparison corrections. The tabulation includes WM structure names, affected cognitive abilities quantified using MoCA, t statistics with degrees of freedom (d.f.) equal to N - 2, where N is the number of participants with CMBs in the respective structure, and FDR-corrected q values (second, fourth and fifth columns, respectively). Only statistically significant findings are listed.