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. Author manuscript; available in PMC: 2022 Dec 18.
Published in final edited form as: Sci Signal. 2020 Aug 11;13(644):eabc4218. doi: 10.1126/scisignal.abc4218

Figure 1: A model in which Fusobacterium nucleatum invasion into colorectal cancer cells induces cytokine secretion and invasion.

Figure 1:

(A to C) A conceptual model of the findings of Casasanta et al. using a cultured CRC cell line, not actual CRC tissues. (A) F. nucleatum can invade CRC cells in a manner dependent on the bacterial adhesin protein FAP2. (B) Invasion of F. nucleatum induces secretion of IL-8 and CXCL1 by the host cell. (C) These cytokines, in turn, promote migration in both infected and uninfected cancer cells.