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. 2022 Dec 18;10:187. doi: 10.1186/s40478-022-01492-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — The expression of activated MMP9 and Col-IV after SAH. The MMP9 protein expression level was markedly increased in the SAH group compared to those of Sham group (A, B). The level of Col-IV protein was significantly decreased in the SAH group compared to that of Sham group (C, D). Compared with that of Sham group, the enzymatic activity of MMP9 in SAH group was significantly enhanced (E, F). “※” in B, D and F indicating P < 0.05 compared with that of Sham group, n = 5 per group. “Square box” indicating representative MMP9 zymography; “Arrow” in E showing the activated MMP9. Abbreviations: GFAP: glial fibrillary acidic protein; IPAD: intramural periarterial drainage; Col-IV: Collagen Type IV; MMP9: matrix metalloproteinase 9; SAH: subarachnoid hemorrhage