Table 2.
CpGs prospectively associated with incident diabetes in a Cox proportional hazards model at a nominal p value < 0.01
| CpG | Chr | Gene | Function | Adjusted for covariatesa | Adjusted for covariates + fasting glucose | Adjusted for covariates + HOMA-IR | |||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | ||||
| cg11024682 | 17 | SREBF1 | Obesity, type 2 diabetes and insulin sensitivity | 1.92 (1.35, 2.74) | 0.0003 | 1.66 (1.16, 2.37) | 0.005 | 1.66 (1.17, 2.35) | 0.005 |
| cg07750706 | 6 | PLAGL1 | Transient neonatal diabetes mellitus | 0.63 (0.47, 0.83) | 0.0009 | 0.67 (0.51, 0.89) | 0.005 | 0.66 (0.5, 0.87) | 0.003 |
| cg23053438 | 3 | HEG1 | Regulator of heart and vessel formation | 0.64 (0.49, 0.83) | 0.001 | 0.66 (0.51, 0.87) | 0.003 | 0.67 (0.51, 0.88) | 0.004 |
| cg01885480 | 15 | OAZ2 | Polyamine biosynthesis, type 2 diabetes | 0.64 (0.49, 0.84) | 0.001 | 0.67 (0.51, 0.88) | 0.003 | 0.69 (0.53, 0.9) | 0.007 |
| cg06500161 | 21 | ABCG1 | Cholesterol and phospholipids transport | 1.54 (1.16, 2.03) | 0.003 | 1.38 (1.03, 1.84) | 0.03 | 1.27 (0.95, 1.69) | 0.11 |
| cg22710955 | 7 | POP7 | Ribosome biogenesis | 0.66 (0.5, 0.87) | 0.003 | 0.70 (0.53, 0.92) | 0.01 | 0.69 (0.52, 0.91) | 0.009 |
| cg20463945 | 6 | C6orf136 | Uncharacterized function | 0.70 (0.54, 0.9) | 0.006 | 0.75 (0.58, 0.97) | 0.03 | 0.69 (0.54, 0.9) | 0.006 |
| cg15269194 | 7 | FAM3C | Type 2 diabetes and non-alcoholic fatty liver disease | 0.70 (0.54, 0.9) | 0.006 | 0.75 (0.59, 0.97) | 0.03 | 0.69 (0.53, 0.9) | 0.006 |
| cg27089547 | 16 | ZNF747 | Uncharacterized function | 0.69 (0.52, 0.9) | 0.006 | 0.72 (0.55, 0.94) | 0.02 | 0.70 (0.54, 0.92) | 0.01 |
| cg20595300 | 9 | UHRF2 | Cell-cycle regulation, tumorigenesis | 0.70 (0.54, 0.91) | 0.007 | 0.75 (0.58, 0.97) | 0.03 | 0.74 (0.57, 0.95) | 0.02 |
| cg19048496 | 16 | TCEB2 | Transcription elongation and cellular senescence | 0.69 (0.53, 0.9) | 0.007 | 0.70 (0.53, 0.91) | 0.007 | 0.73 (0.56, 0.96) | 0.02 |
| cg08728520 | 20 | COMMD7 | NF-kappa-B complex activity | 0.68 (0.51, 0.9) | 0.007 | 0.70 (0.53, 0.93) | 0.01 | 0.69 (0.51, 0.91) | 0.009 |
| cg06935581 | 16 | DECR2 | Lipid metabolism | 0.68 (0.51, 0.9) | 0.007 | 0.70 (0.53, 0.93) | 0.01 | 0.70 (0.52, 0.92) | 0.01 |
| cg00291981 | 3 | BSN | Spatial organization of synaptic vesicle cluster | 0.69 (0.53, 0.91) | 0.007 | 0.72 (0.55, 0.94) | 0.02 | 0.70 (0.54, 0.92) | 0.009 |
| cg25944898 | 11 | PRDX5 | Cellular protection against oxidative stress | 0.69 (0.52, 0.91) | 0.008 | 0.71 (0.54, 0.93) | 0.01 | 0.71 (0.54, 0.94) | 0.02 |
| cg27555392 | 1 | FBXO42 | Protein-ubiquitin ligases | 0.69 (0.53, 0.91) | 0.009 | 0.72 (0.55, 0.95) | 0.02 | 0.71 (0.54, 0.94) | 0.02 |
Model adjusted for age, smoking status (never, former, current), alcohol consumption (never, former, current), sex, education level (less than high school, some high school, high school or more), Houseman cell proportions (CD8T, CD4T, NK, B cells and monocytes), five genetic PCs and study center (Arizona, Oklahoma or Dakota)