Figure 3.

Dermal reactions and faecal larval content in the challenge study

The area of induration (A), area of erythema (B), and duration of dermal symptoms (C) at the inoculation site after each vaccination and challenge with non-attenuated larvae. Induration and erythema were measured 2 days after each inoculation (both groups were measured for the challenge inoculation). The number of Necator americanus larvae recovered per g of faeces cultured (D) and the N americanus DNA intensity in faecal culture (E) from samples collected on day 161. Datapoints are for individual participants, horizontal lines show the group median, and error bars show the 95% CI. *Calculated using exact sign test. †Calculated using Mann-Whitney U test.