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Schematic representation of HIF-1α/YAP signaling mediating glucose/iodine metabolism program in papillary thyroid carcinoma. The HIF-1α/YAP complexes bound to GLUT1 gene promoter and directly activated its transcription to accelerate glycolysis under hypoxia. Meanwhile, it indirectly activates the MAPK signaling pathway, resulting in a decrease in NIS and iodine uptake.
