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. 2023 Jan 1;19(1):156–166. doi: 10.7150/ijbs.76148

Figure 3.

Figure 3

5a-IRDye homes in on orthotopically implanted BxPC-3 tumors. Nu/nu mice were orthotopically implanted with a Matrigel solution containing BxPC-3 cells or a Matrigel solution without cells (n=3-4 mice). After 18 days, mice were injected i.v. with 5a-IRDye (1.2 nmol), and NIR images were acquired after 24 h. A control mouse, which was not surgically manipulated, was injected with the vehicle and used as a reference for quantification of autofluorescence in the NIR region. (A) Representative fluorescence images of the exposed pancreas of control and tumor-bearing mice injected with or without 5a-IRDye as indicated. (B) Ex vivo fluorescence imaging and photographs of the removed pancreas. Arrow, pancreatic cancer lesions. (C) Ex vivo biodistribution of 5a-IRDye in selected organs. Bars: mean ± SE of 1-4 mice.