Table 5.

Univariate and multivariate Cox regression model of RF^+/- on overall survival

Covariate	Univariate				Multivariate
	N	HR	95% CI	p-value	N	HR	95% CI	p-value
Risk Factor (RF)	74			0.044*	62			0.024*
No RF	17	1.00	Ref.		14	1.00	Ref.
RF+	17	6.97	1.52-31.88	0.012*	15	18.19	2.08-158.79	0.009*
RF-	40	5.07	1.18-21.78	0.029*	33	8.75	1.09-69.67	0.040*
Treatment	79			0.009*	62			0.001*
Neoadjuvant	17	1.00	Ref.		9	1.00	Ref.
Adjuvant	51	0.29	0.13-0.65	0.003*	42	0.12	0.04-0.38	<0.001*
Other	11	0.69	0.25-1.89	0.479	11	0.15	0.03-0.73	0.020*
Age (≥73years)	83	2.09	1.00-4.37	0.050*	62	4.13	1.27-13.43	0.018*
Tumor size	74			0.026*
T0	2	NA	NA	NA
T1	31	0.18	0.05-062	0.007*
T2	35	0.16	0.04-0.53	0.003*
T3-T4	5	1.00	Ref.
Prominent inflammation (Yes)	71	0.42	0.12-1.41	0.163

N: number of patients; HR: Hazard Ratio; NA: not available (not possible to calculate)

RF⁺: [(p-NDRG1(N)⁺ / NDRG1(N)⁺) / (p-NDRG1(N)^- / NDRG1(N)⁺)]

RF^-: p-NDRG1(N)^- / NDRG1(N)^-.