TABLE 1.
Main Characteristics of the Study Population
| Variables, Units | Overall, N = 17 | Prone Position First, N = 9 | Semirecumbent Position First, N = 8 |
|---|---|---|---|
| Age, yr | 61 (57–71) | 61 (55–77) | 63 (56–68) |
| Sex, male, n (%) | 15 (88) | 8 (89) | 7 (88) |
| Body mass index, kg/m² | 27 (25–31) | 27 (26–31) | 27 (25–31) |
| Simplified Acute Physiologic Score II, at inclusion | 29 (22–33) | 27 (22–33) | 30 (24–33) |
| Comorbidities, n (%) | |||
| Cancer | 7 (41) | 4 (44) | 3 (38) |
| Diabetes | 2 (12) | 1 (11) | 1 (13) |
| Hypertension | 10 (59) | 6 (67) | 4 (50) |
| Chronic obstructive pulmonary disease | 1 (6) | 1 (11) | 0 |
| Chronic heart diseases | 3 (18) | 3 (33) | 0 |
| Chronic liver diseases | 0 | 0 | 0 |
| Chronic renal failure | 1 (6) | 0 | 1 (13) |
| Immunodepression | 3 (18) | 2 (22) | 1 (13) |
| Time from symptom onset to hospital admission, d | 9 (5–10) | 9 (6–10) | 9 (3–10) |
| Time from symptom onset to ICU admission, d | 9 (6–11) | 9 (6–11) | 9 (7–10) |
| Time from symptom onset to enrollment, d | 10 (8–12) | 10 (8–12) | 11 (8–12) |
| High-flow nasal O2 gas flow at enrollment, L/min | 30 (30–50) | 30 (30–50) | 30 (30–55) |
| Arterial pH at enrollment | 7.45 (7.44–7.5) | 7.44 (7.44–7.5) | 7.47 (7.44–7.5) |
| Paco2 at enrollment, mm Hg | 32 (30–33) | 32 (29–33) | 33 (31–34) |
| Pao2/Fio2 at enrollment, mm Hg/% | 115 (88–139) | 130 (107–151) | 96 (74–128) |
| Respiratory rate at enrollment, breaths/min | 25 (20–33) | 22 (20–26) | 32 (23–39) |
| Heart rate at enrollment, beats/min | 75 (69–88) | 75 (67–89) | 76 (71–89) |
| Mean arterial pressure at enrollment, mm Hg | 76 (58–99) | 90 (63–132) | 66 (58–77) |
| Length of ICU stay, d | 15 (9–27) | 14 (9–31) | 16 (11–23) |
| Need for endotracheal intubation after enrollment, n (%) | 5 (29) | 2 (22) | 3 (38) |
| Length of mechanical ventilation after intubation, d | 24 (17–36) | 36 (20–51) | 24 (11–29) |
| 60-d mortality, n (%) | |||
| Overall | 1 (6) | 0 | 1 (13) |
| Intubated patients | 1 (6) | 0 | 1 (13) |
| Nonintubated patients | 0 | 0 | 0 |
Data are expressed as the median (interquartile range, 25–75%) unless otherwise specified.