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. 2022 Dec 19;7:392. doi: 10.1038/s41392-022-01247-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — CYT387 treatment enhanced viral replication in bat intestinal organoids in the early stage of viral growth. Bat and human intestinal organoids were pretreated with 1 μg/ml CYT387 or DMSO overnight. After inoculation with WT SARS-CoV-2 or CoV-HKU4, the pretreated bat and human organoids were incubated with 1 μg/ml CYT387 or DMSO. At indicated time points after infection, cell-free media were collected and subjected to viral load detection and viral titration. Data represent mean and s.d. in each organoid line, n = 3. Ordinary one-way ANOVA with Tukey’s multiple comparison test. Viral load and viral titer of SARS-CoV-2 in treated and mock-treated bat organoids (a) and human organoids (b). Viral load and viral titer of CoV-HKU4 in treated and mock-treated bat organoids (c) and human organoids (d)