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Amino acid Pile-Up diagram of Sm-PEPCK and human PEPCKm and PEPCKc. The amino acid numbering for Sm-PEPCK appears in parentheses. Grey lettering represents amino acid sequence homology between S. mansoni and human sequences. Box A, phosphoenolpyruvate-binding site; box B, GTP-binding site; box C, thiol-binding site; box D, guanine-binding site; ∗, stop codon.
