Table 3.

Clinical characteristics of patients who had a history of NSAID-induced anaphylactic reactions.

	Diagnosis	Baseline tryptase	Total IgE	NSAID trigger	Clinical symptoms
Patient nr 1	ISM	13 ng/ml	43 kU/L	Diclofenac	RESP, cutaneous (angioedema)
Patient nr 2	ISM	34 ng/ml	8 kU/L	Diclofenac	Cutaneous, CARDV, GI
Patient nr 3	ISM	11 ng/ml	22 kU/L	Diclofenac	Cutaneous, SYNC
Patient nr 4	MMAS	21 ng/ml	96 kU/L	Uncertain (ibuprofen and paracetamol in combination)	Cutaneous, RESP, SYNC
Patient nr 5	ISM	30 ng/ml	n/a	Nimesulide	Dyspnea, loss of consciousness
Patient nr 6	ISM	21 ng/ml	n/a	Nimesulide	Pruritus in hand palms and feet, urticaria, dyspnea, SYNC
Patient nr 7	MMAS	14 ng/ml	n/a	Ibuprofen	Dyspnea, tachycardia, hypotension, vertigo, SYNC
Patient nr 8	ISM	25 ng/ml	n/a	Nimesulide	Angioedema, dyspnea, hypotension
Patient nr 9	ISM	20 ng/ml	n/a	Diclofenac	Nausea, vomiting, diarrhea, fatigue, dyspnea
Patient nr 10	MMAS	56 ng/ml	n/a	Ibuprofen	Urticaria, hypotension
Patient nr 11	MMAS	19 ng/ml	50 kU/L	Diclofenac	Dyspnea, hypotension, SYNC, urticaria

Abbreviations: NSAID, non-steroidal anti-inflammatory drug; ISM, indolent systemic mastocytosis; MMAS, monoclonal mast cell activation syndrome; SYNC, syncope; CARDV, cardiovascular; RESP, respiratory; GI, gastrointestinal.