Table 2.
Associations between METS-IR and clinical outcomes.
| Exposure | Unadjusted | Model 1 | Model 2 | Model 3 |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Total stroke | ||||
| Per SD increment | 1.26 (1.19, 1.33) | 1.26 (1.19, 1.34) | 1.29 (1.21, 1.37) | 1.33 (1.25, 1.42) |
| Categories | ||||
| Q1-Q2 | Reference | Reference | Reference | Reference |
| Q3-Q4 | 1.49 (1.32, 1.68) | 1.48 (1.31, 1.67) | 1.52 (1.34, 1.72) | 1.57 (1.38, 1.79) |
| Quartiles | ||||
| Q1 | Reference | Reference | Reference | Reference |
| Q2 | 0.95 (0.79, 1.15) | 0.97 (0.80, 1.18) | 0.96 (0.80, 1.17) | 0.97 (0.80, 1.18) |
| Q3 | 1.30 (1.09, 1.55) | 1.29 (1.08, 1.54) | 1.30 (1.09, 1.55) | 1.34 (1.12, 1.61) |
| Q4 | 1.60 (1.35, 1.90) | 1.63 (1.38, 1.93) | 1.71 (1.43, 2.03) | 1.80 (1.50, 2.17) |
| P for trend | <0.001 | <0.001 | <0.001 | <0.001 |
| Ischemic stroke | ||||
| Per SD increment | 1.32 (1.23, 1.41) | 1.32 (1.24, 1.41) | 1.35 (1.26, 1.44) | 1.39 (1.29, 1.49) |
| Categories | ||||
| Q1-Q2 | Reference | Reference | Reference | Reference |
| Q3-Q4 | 1.61 (1.40, 1.85) | 1.60 (1.39, 1.84) | 1.63 (1.41, 1.87) | 1.68 (1.45, 1.95) |
| Quartiles | ||||
| Q1 | Reference | Reference | Reference | Reference |
| Q2 | 1.01 (0.81, 1.25) | 1.03 (0.83, 1.28) | 1.03 (0.83, 1.28) | 1.04 (0.84, 1.30) |
| Q3 | 1.47 (1.21, 1.79) | 1.46 (1.20, 1.78) | 1.47 (1.20, 1.80) | 1.52 (1.24, 1.87) |
| Q4 | 1.75 (1.45, 2.12) | 1.79 (1.48, 2.17) | 1.85 (1.52, 2.26) | 1.96 (1.60, 2.42) |
| P for trend | <0.001 | <0.001 | <0.001 | <0.001 |
| Hemorrhagic stroke | ||||
| Per SD increment | 0.98 (0.87, 1.11) | 0.98 (0.87, 1.11) | 1.02 (0.90, 1.15) | 1.01 (0.89, 1.15) |
| Categories | ||||
| Q1-Q2 | Reference | Reference | Reference | Reference |
| Q3-Q4 | 1.06 (0.83, 1.34) | 1.05 (0.83, 1.33) | 1.12 (0.87, 1.42) | 1.12 (0.87, 1.44) |
| Quartiles | ||||
| Q1 | Reference | Reference | Reference | Reference |
| Q2 | 1.02 (0.73, 1.44) | 1.02 (0.73, 1.44) | 1.01 (0.71, 1.42) | 0.96 (0.68, 1.35) |
| Q3 | 1.13 (0.81, 1.57) | 1.12 (0.80, 1.56) | 1.13 (0.81, 1.59) | 1.12 (0.79, 1.58) |
| Q4 | 1.01 (0.72, 1.42) | 1.01 (0.72, 1.42) | 1.10 (0.78, 1.57) | 1.07 (0.74, 1.55) |
| P for trend | 0.817 | 0.835 | 0.462 | 0.530 |
Model 1, adjusted for age; sex, Model 2, adjusted for heart rate, SBP, DBP, current smoker, current drinker, hyperlipidemia, Charlson comorbidity index, diabetes, and coronary heart disease based on model 1, Model 3; included variables in model 2 and further adjusted for uric acid, eGFR, cystatin C, TC, TG, LDL-C, HbA1c, FPG, Hcy, hsCRP, use of statins, use of aspirins, use of insulins, use of oral antidiabetic drugs, and antihypertensive drugs.
SD, standard deviation; HR, hazard ratio; CI, confidence interval. Other abbreviations as presented in Table 1 .