Table 5.

The correlation among hub crosstalk genes in periodontitis and Parkinson’s disease, respectively.

Hub gene	Hub gene	Cor.	p-value	Sig.
Periodontitis
FMNL1	TCIRG1	0.776680579	8.72E-64	***
TCIRG1	FMNL1	0.776680579	8.72E-64	***
FMNL1	RNASE6	0.630304404	9.84E-36	***
RNASE6	FMNL1	0.630304404	9.84E-36	***
RNASE6	TCIRG1	0.623645546	8.28E-35	***
TCIRG1	RNASE6	0.623645546	8.28E-35	***
FMNL1	PLAUR	0.519504303	7.95E-23	***
PLAUR	FMNL1	0.519504303	7.95E-23	***
PLAUR	TCIRG1	0.463852082	6.06E-18	***
TCIRG1	PLAUR	0.463852082	6.06E-18	***
PLAUR	RNASE6	0.356920531	9.59E-11	***
RNASE6	PLAUR	0.356920531	9.59E-11	***
MANSC1	PLAUR	−0.501651214	3.67E-21	***
PLAUR	MANSC1	−0.501651214	3.67E-21	***
MANSC1	RNASE6	−0.508910042	7.94E-22	***
RNASE6	MANSC1	−0.508910042	7.94E-22	***
MANSC1	TCIRG1	−0.583097828	1.25E-29	***
TCIRG1	MANSC1	−0.583097828	1.25E-29	***
FMNL1	MANSC1	−0.687320353	1.13E-44	***
MANSC1	FMNL1	−0.687320353	1.13E-44	***
Parkinson’s disease
FMNL1	TCIRG1	0.714413971	1.39E-88	***
TCIRG1	FMNL1	0.714413971	1.39E-88	***
MANSC1	PLAUR	0.542333646	3.87E-44	***
PLAUR	MANSC1	0.542333646	3.87E-44	***
FMNL1	PLAUR	0.375957267	3.05E-20	***
PLAUR	FMNL1	0.375957267	3.05E-20	***
PLAUR	RNASE6	0.373867758	5.10E-20	***
RNASE6	PLAUR	0.373867758	5.10E-20	***
PLAUR	TCIRG1	0.369494651	1.48E-19	***
TCIRG1	PLAUR	0.369494651	1.48E-19	***
RNASE6	TCIRG1	0.294141212	1.22E-12	***
TCIRG1	RNASE6	0.294141212	1.22E-12	***
MANSC1	RNASE6	0.268167983	1.12E-10	***
RNASE6	MANSC1	0.268167983	1.12E-10	***
FMNL1	MANSC1	0.181137877	1.61E-05	***
MANSC1	FMNL1	0.181137877	1.61E-05	***
FMNL1	RNASE6	0.151556057	0.000319114	***
RNASE6	FMNL1	0.151556057	0.000319114	***
MANSC1	TCIRG1	0.110844015	0.008657743	**
TCIRG1	MANSC1	0.110844015	0.008657743	**

**p <= 0.01, ***p <= 0.001.