Table 2.
The expression level of the PD-1/PD-L1 in animal models.
| First author | PD-1/PD-L1 | Animal | Exposure | Sample | Cell types | Method | Expression level | Ref. |
|---|---|---|---|---|---|---|---|---|
| Youliang Zhao | PD-1 | 6-8 weeks male C57BL/6 mice | Silica | Lung | / | WB IHC FCM PCR |
Upregulation | (28) |
| PD-L1 | Lung | / | Upregulation | |||||
| Ye Lu | PD-L1 | 4-6 weeks female C57BL/6 mice | BLM | Lung | Fibroblasts | WB IHC |
Upregulation | (29) |
| Xia Guo | PD-L1 | 12-16 weeks male C57BL/6 mice | BLM | Lung | Fibroblasts | IF | Upregulation | (17) |
| Dong Wang | PD-1 | 8 weeks male C57BL/6 mice | BLM | Lung | / | IHC | Upregulation | (30) |
| Peripheral blood | CD4+ T cells | FCM | Upregulation | |||||
| Lu Cui | PD-L1 | 11-12 weeks male C57BL/6 mice | BLM | Lung | Fibroblasts | Mass cytometry IF FCM |
Upregulation | (20) |
| JUN-induced lung fibrosis mice | JUN | Lung | Fibroblasts | Upregulation | ||||
| IL-6 knock out mice and wildtype | BLM | Lung | Fibroblasts | Upregulation | ||||
| NSG mice | Primary human fibrotic lung fibroblasts engraftation | Lung | Fibroblasts | Upregulation | ||||
| PD-1 | 11-12 weeks male C57BL/6 mice | BLM | Lung | CD8+T cells | Mass cytometry | Upregulation | ||
| Yan Geng | PD-L1 | 6-8 weeks female NSG mice | CD274high and CD274low IPF lung normal fibroblasts injection | Lung | Fibroblasts | PCR RNA-seq |
Upregulation | (21) |
| Ke Ni | PD-L1 | 4-6 weeks Rag2-/-γc-/-mice | BLM | Lung | MSC | FCM | Upregulation | (22) |
| Lindsay J. Celada | PD-1 | 7-9 weeks old C57BL/6J mice | BLM | Lung | CD4+ T cells | FCM | Upregulation | (25) |
IPF, idiopathic pulmonary fibrosis; PD-1, programmed cell death 1; PD-L1, programmed death-ligand 1; IF, immunofluorescence; FCM, flow cytometry; IHC, immunohistochemistry; WB, western blot; PCR, polymerase chain reaction; BLM, bleomycin; NSG, NOD-SCID-IL2Rγc–/–; RNA-seq, RNA sequencing; MSC, mesenchymal stem cell.