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. 2022 Dec 5;13:1024039. doi: 10.3389/fimmu.2022.1024039

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Copyright © 2022 Maus, Leontovich, Moore, Fogarty, Guo, Davidson, Tekin, Atherton, Schimke, Dicke, Chen and Markovic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regional interactions within cellular communities. (A) Representative illustration of cellular community definition. Each cell is defined by its 75 nearest neighbors. (B) Heatmap depicting cellular composition of 11 community clusters and relative frequency of each community cluster across the dataset. (C) Representative FOVs illustrating macroarchitecture of community clusters in recurrence and no recurrence cohorts. Community colors correlate with the heat map groups in panel (B, D) Box plot comparing community cluster frequencies between patients based on recurrence status. ns indicates no significance, ** indicates p value <0.01.