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. 2022 Dec 5;13:1024039. doi: 10.3389/fimmu.2022.1024039

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Copyright © 2022 Maus, Leontovich, Moore, Fogarty, Guo, Davidson, Tekin, Atherton, Schimke, Dicke, Chen and Markovic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenotypic composition of cell-centered neighborhoods differs based on index cell and clinical recurrence status. (A) Illustration and visualization of all TCCN and CTCN with at least one immune cell (TCCN) or tumor cell (CTCN) present in tumor FOVs. In TCCN, index (center) tumor cell is indicated in blue, in CTCN index CTL is indicated in green, tumor cell neighbors are brown, immune cell neighbors are magenta. (TCCN n=983,823 and CTCN n=37,402) (B) Box plot comparing neighborhood frequencies of immune composition between patients based on recurrence status. Distribution of patients displayed on box plot as green circles (no recurrence) and red triangles (recurrence). (C) Distribution of tumor cell counts in TCCN and CTCN in patient cohorts. Acronyms are as follows B cells (BC), Cytotoxic T cell (CTC), Dendritic cells (DC), Macrophages (MAC), T helper cells (THC), T regulatory cells (Treg). NS indicates no significance, * indicates p value <0.01.