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. 2022 Dec 5;13:1024039. doi: 10.3389/fimmu.2022.1024039

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Copyright © 2022 Maus, Leontovich, Moore, Fogarty, Guo, Davidson, Tekin, Atherton, Schimke, Dicke, Chen and Markovic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Homotypic and heterotypic cellular interactions within TCCN and CTCN. (A) Frequency of tumor-only and immune-populated neighborhoods were computed in TCCN of patients that recurred vs those that did not. Frequency of immune-populated TCCNs were further categorized based on presence of a single immune cell subset (homotypic) or two distinct immune cell classes (heterotypic) within the neighborhood. (B) Frequency of tumor only, immune homotypic and immune heterotypic neighborhoods were similarly assessed in CTCN of patients that experienced recurrence vs those that did not. p values indicated on right side of each bar. 0 represents p value< 0.00001.