Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 5;13:1024039. doi: 10.3389/fimmu.2022.1024039

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Maus, Leontovich, Moore, Fogarty, Guo, Davidson, Tekin, Atherton, Schimke, Dicke, Chen and Markovic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Functional expression of PD1-PDL1 contextualized in the TCCN of the tumor-immune climate. (A) Virtual H&E of representative tumor FOVs. (B) MxIF overlay details tumor-immune landscape (TILs, myeloid cells, tumor cells) and PD1 and PDL1 expression in the same FOVs. (C) R plots identify spatial TCCN with at least one PD1+ neighbor (index tumor cell: teal, PD1+ cell: yellow, immune cell: purple, tumor cell: brown). (D) Box plot comparing frequency PD1+ TIL subsets as neighbors in TCCN between patients based on recurrence status. Distribution of patients displayed on box plot as green circles (no recurrence) and red triangles (recurrence). Acronyms are as follows B cells (BC), Cytotoxic T cell (CTC), T helper cells (THC), T regulatory cells (Treg). * indicates p value <0.01.