Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 5;13:1024039. doi: 10.3389/fimmu.2022.1024039

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Maus, Leontovich, Moore, Fogarty, Guo, Davidson, Tekin, Atherton, Schimke, Dicke, Chen and Markovic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Summary of regional and paracrine level differences within metastatic lymph nodes based on recurrence status. Regional cellular communities identified a cluster comprised of primarily DCs and tumor cells to be enriched in patients that did not experience recurrence. Paracrine tumor-centric neighborhoods showed increased immune cell diversity while CTL-centric neighborhoods were enriched for DCs in patients that did not recur. Immune cell interactions within neighborhoods favored DC and CTL in patients that did not recur and macrophages and CTL in patients that did experience recurrence. Illustration was created using Biorender.