TABLE 2.
Results of multivariate Cox regression analysis of OS in patients with PLC treated with ICIs
| Characteristics | Univariate cox | Multivariate cox | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% Cl | p‐value | Hazard radio | 95% Cl | p‐value | |
| Age (≥60 years) | 1.005 | 0.472–2.141 | 0.990 | |||
| Female | 0.369 | 0.160–0.851 | 0.019 | 0.284 | 0.111–0.728 | 0.009 |
| BMI | 0.905 | 0.815–1.004 | 0.060 | |||
| Drinking history | 0.631 | 0.286–1.391 | 0.254 | |||
| Smoking history | 0.741 | 0.375–1.463 | 0.387 | |||
| ECOG‐PS | ||||||
| 1 | 1.296 | 0.640–2.622 | 0.471 | |||
| 2 | 2.249 | 0.807–6.263 | 0.121 | |||
| Second‐line therapy | 1.127 | 0.493–2.575 | 0.777 | |||
| Child‐Pugh Class(B) | 1.771 | 0.853–3.677 | 0.125 | |||
| Ascites | 1.179 | 0.552–2.515 | 0.671 | |||
| Comorbidity | ||||||
| Hypertension | 1.011 | 0.460–2.223 | 0.978 | |||
| Diabetes | 0.970 | 0.374–2.513 | 0.950 | |||
| Hepatitis B | 1.436 | 0.440–4.689 | 0.551 | |||
| Liver cirrhosis | 1.375 | 0.626–3.02 | 0.427 | |||
| Splenomegaly | 4.357 | 2.188–8.677 | <0.001 | 3.997 | 1.517–10.531 | 0.005 |
| Previous treatment | ||||||
| Surgery | 0.501 | 0.195–1.289 | 0.152 | |||
| Ablation | 0.736 | 0.321–1.684 | 0.467 | |||
| TACE | 1.185 | 0.605–2.319 | 0.621 | |||
| HAIC | 0.961 | 0.337–2.738 | 0.940 | |||
| Laboratory finding | ||||||
| WBC count (×109/L) | 0.907 | 0.780–1.056 | 0.210 | |||
| Lymphocyte count (≥1.1 × 109/L) | 0.437 | 0.227–0.844 | 0.014 | 0.990 | 0.423–2.319 | 0.982 |
| Neutrophil count (×109/L) | 0.967 | 0.816–1.145 | 0.696 | |||
| AST(U/L) | 1.003 | 1.000–1.006 | 0.038 | 1.004 | 1.000–1.007 | 0.040 |
| ALT(U/L) | 1.002 | 0.998–1.006 | 0.278 | |||
| Total bilirubin (≥34 μmol/L) | 0.935 | 0.224–3.895 | 0.926 | |||
| ALB (≥35 g/L) | 0.504 | 0.259–0.981 | 0.044 | 0.734 | 0.337–1.598 | 0.435 |
| PT (s) | 1.232 | 1.047–1.449 | 0.012 | 0.944 | 0.760–1.172 | 0.599 |
| AFP (≥200 ng/ml) | 2.664 | 1.213–5.851 | 0.015 | 2.411 | 1.067–5.448 | 0.034 |
| Platelet count (<100 × 109/L) | 2.504 | 1.204–5.209 | 0.014 | 1.803 | 0.597–5.443 | 0.296 |
Abbreviations: AFP, alpha‐fetoprotein; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; ECOG‐PS, Eastern Cooperative Oncology Group performance status; HAIC, hepatic arterial infusion chemotherapy; PT, prothrombin time; TACE, transcatheter arterial chemoembolization; WBC, white blood cell. In univariate cox, bold values indicate variables that were included in the multivariate cox regression analysis. In multivariate cox, bold values indicate statistically significance.